Anthony Rizzo homered, doubled and started Chicago's winning rally with a single off Burke Badenhop (0-1) as the Reds' bullpen failed again. Herrera singled home the go-ahead run, and Ross doubled home two more.
Starting pitcher Travis Wood drove in the final run with a pinch-hit grounder.
Jason Motte (1-0) got Jay Bruce to foul out with the bases loaded in the 10th inning, keeping it tied at 3. Hector Rondon retired the side in order for his fourth save in five chances.
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